Research at Analytical DNA Nanotechnology Laboratory (ADNLab) is at the interface of bioanalytical chemistry and DNA nanotechnology. We consider DNA both as important biomarkers for diverse biological processes and clinical diagnostics and also as a class of highly programmable engineering material.
New building blocks and simulation tools for DNA nanotechnology
We aim to enrich the current toolbox of DNA nanotechnology by introducing new experimental and simulation strategies to better manipulate and understand DNA as an emerging class of engineering material.
New design principles for ultraspecific DNA hybridization probes
We are also interested in exploring new design principles for engineering ultraspecific DNA hybridization probes for the ultrasensitive detection of low abundant mutations in clinical samples. Our studies cover both upstream thermodynamics and kinetics for guiding the probe design and downstream assay pipelines for disease diagnosis in real clinical settings.
New detection platforms for point-of-care testing
Leveraging our expertise in DNA nanotechnology and capability of multi-length-scale engineering, we aim to develop novel diagnostic platforms that are portable, rapid, and inexpensive, with minimal barriers for technology transfer and adoption.
