Selected Publications
代表性论文
1. Zhang, Q.; Zheng, J.; Wang, Y.; Xu, S.; Wang, W.; Xu, J.;* Zhang, J.-R.;* Li, F.;* Zhu, J.-J.* A Diffusion-Based Synthetic Cell Communication Network Enabled by a Multitasking Deoxyribonucleic Acid Nanomachine. Journal of the American Chemical Society, 2025, 147, 15806-15813
2. Wu, Y.#; Wang, G.A.#; Yang, Q.; Li, F.* Native Characterization of Noncanonical Nucleic Acid Thermodynamics via Programmable Dynamic DNA Chemistry. Journal of the American Chemical Society, 2024, 146, 26, 18041–18049.
3. Wu, L.#; Wang, G.A.#; Li, F.* Plug-and-Play Module for Reversible and Continuous Control of DNA Strand Displacement Kinetics. Journal of the American Chemical Society, 2024, 146, 10, 6516–6521.
4. Huang, D.#; Deng, H.#; Zhou, J.#; Wang, G. A.; Lei, Q.; Guo, C.; Peng, W.; Liang, P.; Shen, C.; Ying, B.*; Li, W.*; Li, F.* Mismatch-Guided Deoxyribonucleic Acid Assembly Enables Ultrasensitive and Multiplex Detection of Low-Allele-Fraction Variants in Clinical Samples. Journal of the American Chemical Society, 2023, 145, 20412–20421.
5. Wang, G. A.#; Wu, X.#; Chen F.; Shen, C.; Yang, Q.; Li, F.* Toehold-exchange-based activation of aptamer switches enables high thermal robustness and programmability. Journal of the American Chemical Society, 2023, 145, 2750–2753.
6. Wang, G.A.; Xu, J.; Traynor, S. M.; Chen, H.; Eljabu, F.; Wu, X.; Yan, H.; Li, F.* DNA balance for native characterization of chemically modified DNA. Journal of the American Chemical Society, 2021, 143, 13655–13663.
7. Yang, X.; Tang, Y.; Traynor, S. M.; Li, F.* Regulation of DNA strand displacement using allosteric DNA toehold. Journal of the American Chemical Society, 2016, 138, 14076-14082.
8. Gao, L.; Zhang, R.; Tang, Y.;* Li, F.* Engineering a proximity biosensor via constitutional dynamic chemistry. Angewandte Chemie International Edition, 2025, 65, e202425644.
9. Guo, C.#; Deng, H.#; Yang, Q.#; Huang, D.; Shen, C.; Wang, G.A.; Li, F.* Coding intrinsic disorder into DNA hybridization probes enables discrimination of single nucleotide variants over wide and tunable temperature ranges. Angewandte Chemie International Edition, 2023, 63, e202314386.
10. Traynor, S. M.; Wang, G. A.; Pandey, R.; Li, F.*; Soleymani, L.* Dynamic Bio‐Barcode Assay Enables Electrochemical Detection of a Cancer Biomarker in Undiluted Human Plasma: A Sample‐In‐Answer‐Out Approach. Angewandte Chemie International Edition, 2020, 59, 22617-22622.
11. Chen, B.; Li, H.; Huang, R.; Tang, Y;* Li, F.* Deep learning prediction of electrospray ionization tandem mass spectra of chemically derived molecules. Nature Communications, 2024, 15, 8396.
12. Xu, J.; Wang, G.A.; Gao, L.; Wu, L.; Lei, Q.; Deng, H.; Li, F.* Enabling programmable dynamic DNA chemistry using small-molecule DNA binders. Nature Communications, 2023, 14, 4248.
13. Tang, Y.#; Song, T.#; Gao, L.; Yin, S.; Ma, M.; Tan, Y.; Wu, L.; Yang, Y.; Wang, Y.; Lin, T.*; Li, F.* A CRISPR-based ultrasensitive assay detects attomolar concentrations of SARS-CoV-2 antibodies in clinical samples. Nature Communications, 2022, 13, 4667. (Featured in Editors' Highlights)
14. Wang, G.A.; Xie, X.; Mansour, H.; Chen, F.; Matamoros, G.; Sanchez, A. L.; Fan, C.; Li, F.* Expanding detection windows for discriminating single nucleotide variants using rationally designed DNA equalizer probes. Nature Communications, 2020,11, 5473.
15. Wang, Y.; Yang, Q.; Lin, X.; Chen, D.; Wang, Z.; Chen, B.; Han, H.; Chen, H.; Cai, K.; Li, Q.; Yang, S.*; Tang, Y.*; Li, F.* G4LDB 2.2: a database for discovering and studying G-quadruplex and i-Motif ligands. Nucleic Acids Research, 2022, 50, D150-D160.
2025
107. Gao, L.; Zhang, R.; Tang, Y.*; Li, F.* Engineering a proximity biosensor via constitutional dynamic chemistry. Angewandte Chemie International Edition, 2025, 64, e202425644.
106. Zhang, Q.; Zheng, J.; Wang Y.; Xu, S.; Wang, W.; Xu, J.;* Zhang, J.-R.;* Li, F.;* Zhu, J.-J.* A diffusion-based synthetic cell communication network enabled by a multitasking deoxyribonucleic acid nanomachine. Journal of the American Chemical Society, 2025, 147, 15806-15813.
105. Yang, Q.; Wang, X.; Wang, Y.; Wu, X.; Shi, R.; Wang, Y.; Zhu, H.; Yang, S.*; Tang, Y.*; Li, F.* G4LDB 3.0: a database for discovering and studying G-quadruplex and i-motif ligands, Nucleic Acids Research, 2025, D91-D98.
104. Wu, Y..; Yang, Q.; Wang, G. A.;* Li, F.* Native measurement of aptamer folding and binding energies using a free energy shift assay. JACS Au, 2025, Accepted.
103. Tan, Y.#; Huang, D.#; Wang, G.; Shen, C.; Deng, H.; Li, F.* Concentration-bias-free discrimination of single nucleotide variants using isothermal nucleic acid amplification and mismatch-guided DNA assembly. Analytical Chemistry, 2025, 97, 1917–1924.
102. Shi, R.; Wang, Y.; Yang, Q.;* Li, F.* Selective recognition and ultrasensitive detection of i-motif DNA using a novel fluorescent probe with PCA-enhanced quantification. Analytical Chemistry, 2025, 97, 14693-14699.
101. Kong, C.; Yang, Q.;* Li, F.* A signal amplifier engineered via a cleavable stochastic bipedal DNA walker. Chemical Communications, 2025, 61, 9690-9692.
100. Zhang, T.#; Yang, H.#; Yu, Q. #; Zhang, Y.; Zhang, Y.; Zhu, X.; Xia, X.; Li, F.; Deng, R.* Dynamic, Single-cell Monitoring of RNA Modifications Response to Viral Infection Using a Genetically Encoded Live-cell RNA Methylation Sensor. Angewandte Chemie International Edition, 2025, 64, 9, e202418003.
99. Kong, Y.; Du, Q.; Zhao, D.; Wen, Y.; Zhang, T.; Geng, Z.; Ying, M.; Si, T.; Tian, Y.; Li, F.; Nie, Z.; Xing, H.* DDNA-progrmmed responsive microorganism assembly with controlled patterns and behaviors. Sci. Adv., 2025, 11, Accepted.
2024
98. Wu, Y.#; Wang, G.A.#; Yang, Q., Li, F.* Native Characterization of Noncanonical Nucleic Acid Thermodynamics via Programmable Dynamic DNA Chemistry. Journal of the American Chemical Society, 2024, 146, 26, 18041–18049.
96. Chen, B.#; Li, H.#; Huang R.; Tang, Y.*; Li, F.* Deep learning prediction of electrospray ionization tandem mass spectra of chemically derived molecules. Nature Communications, 2024, 15, 8396.
95. Gao, L.#; Yi, K.#; Tan, Y.; Guo, C.; Zheng, D.; Shen, C.; Li, F.* Engineering gene-specific DNAzymes for accessible and multiplexed nucleic acid testing. JACS Au, 2024, 4, 4, 1664–1672.
94. Dong, T.; Qin, L.; Wang, Z.; Fan, C.; Shen, C.; Feng, P.; Kong, Q. *; Ke, B.*; Ying, B.*; Li, F.* Point-of-Care Diagnosis of Tuberculosis Using a Portable Nucleic Acid Test with Distance-Based Readout. Analytical Chemistry, 2024, 96, 51, 20204-20212.
93. Xu, J.; Deng, H.; Wu, L.; Song, J.; Feng, X.; Liu, Y.; Wang, G.A.*; Li, F.* Binder-Responsive DNA Strand Displacement Enables High-Throughput and High-Fidelity Discovering of Small Molecular DNA Binders. Analytical Chemistry, 2024, 2024, 96, 30, 12213–12216.
92. Dong, T.#; Ding, R.#; Zhou, R.#; Shen, C.; Sheridan, W.; Paez, D.; Zhao, Z.; Wu, P.*; Li, F.* A portable nucleic acid testing platform with photosensitization, 3D-printed multi-piece chip and digital color sensing. Analytical Chemistry, 2024, 96, 17, 6628–6633.
91. Guo, C.; Ding, R.; Zhao, Z.; Guo, J.;* Li, F.* Enrichment strategies for low-abundant single nucleotide mutations. Chemistry an European Journal, 2024, e202402872. (Invited Contribution).
90. Chen, B.; An, L.; Li, F.*; Tang, Y.* Profiling organic pollutants in environmental water by dansylation-based non-targeted liquid chromatography-high resolution mass spectrometry analysis. Canadian Journal of Chemistry, 2024, 102, 581-588.
89. An, L.; Chen, B.; Zhang, Y.; Li, H.; Huang, R.*; Li, F.; Tang, Y.* Compound Similarity Network as a Novel Data Mining Strategy for High-Throughput Investigation of Degradation Pathways of Organic Pollutants in Industrial Wastewater Treatment. Analytical Chemistry, 2024, 96, 9, 3951–3959.
88. Xie, C.; Wang, S.; Li, F.; Meng, L.; Chen, J.; Wang, L.; Yang, J.*
Recyclable VOCs-free eutectic adhesive based on hydrogen bond fusion strategy with robust adhesion, flame retardancy, transparency, high durability, and low-temperature resistance,
Chemical Engineering Journal, 2024, 156079
2023
87. Huang, D.#; Deng, H.#; Zhou, J.#; Wang, G. A.; Lei, Q.; Guo, C.; Peng, W.; Liang, P.; Shen, C.; Ying, B.*; Li, W.*; Li, F.* Mismatch-Guided Deoxyribonucleic Acid Assembly Enables Ultrasensitive and Multiplex Detection of Low-Allele-Fraction Variants in Clinical Samples. Journal of the American Chemical Society, 2023, 145, 37, 20412–20421.
86. Wang, G.A.#; Wu, X.#; Chen, F.; Shen, C.; Yang, Q.; Li, F.* Toehold-Exchange-Based Activation of Aptamer Switches Enables High Thermal Robustness and Programmability. Journal of the American Chemical Society, 2023, 145, 2750–2753.
85. Guo, C.#; Deng, H.#; Yang, Q.#; Huang, D.; Shen, C.; Wang, G.A.; Li, F.* Coding intrinsic disorder into DNA hybridization probes enables discrimination of single nucleotide variants over wide and tunable temperature ranges. Angewandte Chemie International Edition, 2023, 62, e202314386.
83. Peng, W.#; Tan, Y.#; Shen, C.; Tang, Y.; Li, F.* Enabling a universal lateral flow readout for DNA strand displacement via disassembling chemical labels. Chemical Communications, 2023, 59, 8803-8805. (Inside Cover)
82. Wang, G.A.#; Kong, C.; Li, F.*Design and bioanalytical applications of stochastic DNA walkers. Chemical Communications, 2023, 59, 5492-5501. (2023 Pioneering Investigators theme collection; 2023 HOT Articles)
81. Zhang, Q.#; Gao, L.#; Li, F.*, Bi, Y.*Sensing and manipulating single lipid vesicles using dynamic DNA nanotechnology. Nanoscale, 2023, 15, 5158.
80. Xia, X.; Li, F.; Zhang, Y.; Zhu, Y.; Song, S.; He, G.; Zhang, J.; He, Q.; Deng, R.* Wash-Free and High-Contrast Imaging of Single-Nucleotide Variation in Single Cells Using Transcription-Amplified Light-Up RNA Aptamer. Analytical Chemistry, 2023, 95, 10163-10171.
79. Lu, W.*; Guo, Y.; Yue, Y.; Zhang, J.; Fan, L.; Li, F.; Zhao, Y.; Dong, C.; Shuang, S.* Smartphone-assisted colorimetric sensing platform based on molybdenum-doped carbon dots nanozyme for visual monitoring of ampicillin. Chemical Engineering Journal, 2023, 468, 143615.
78. Li, M.; Xie, C.; Li, F.; Wang, X.; Wang, S.; Qin, Z.*; Jiao, T.*; Yang, J.* Recoverable solvent-free small molecular supramolecular pseudoeutectic adhesives with a wide temperature range. Green Chemistry, 2023, 5, 6845-6852.
2022
77. Tang, Y.#; Song, T.#; Gao, L.; Yin, S.; Ma, M.; Tan, Y.; Wu, L.; Yang, Y.; Wang, Y.; Lin, T.*; Li, F.* A CRISPR-based ultrasensitive assay detects attomolar concentrations of SARS-CoV-2 antibodies in clinical samples. Nature Communications, 2022, 13, 4667. (Featured in Editors' Highlights)
76. Wang, Y.; Yang, Q.; Lin, X.; Chen, D.; Wang, Z.; Chen, B.; Han, H.; Chen, H.; Cai, K.; Li, Q.; Yang, S.*; Tang, Y.*; Li, F.* G4LDB 2.2: a database for discovering and studying G-quadruplex and i-Motif ligands. Nucleic Acids Research, 2022, 50, D150-D160.
75. Deng, H.*; Lei, Q.; Wang, C.; Wang, Z.; Chen, H.; Wang, G.; Yang, N.; Huang, D.; Yu, Q.; Yao, M.; Xiao, X.; Zhu, G.; Cheng, C.; Li, Y.; Li, F.; Tian, P.*; Li, W.* A fluorogenic probe for predicting treatment response in non-small cell lung cancer with EGFR-activating mutations. Nature Communications, 2022, 13, 6944.
74. Gao, J.; Gao, L.; Tang, Y.*; Li, F.* Homogeneous protein assays mediated by dynamic DNA nanotechnology. Canadian Journal of Chemistry, 2022, 100, 900-909. (Invited for the CSC Fred Beamish Award Lecture)
73. Lu, W.*; Guo, Y.; Zhang, J.; Yue, Y.; Fan, L.; Li, F.; Dong, C.; Shuang, S.* High Catalytic Activity Nanozyme Based on Cobalt-Doped Carbon Dots for Biosensor and Anticancer Cell Effect. ACS Appl. Mater. Interfaces. 2022, 14, 57206–57214.
72. Yang, P.; Zhou, R.; Hu, J.; Du, L.; Li, F.; Chen, J.*; Hou, X.* Lanthanide Encoded Logically Gated Micromachine for Simultaneous Detection of Nucleic Acids and Proteins by Elemental Mass Spectrometry.
Analytical Chemistry, 2022, 94, 17746–17750.
71. Yang, H.; Li, F.; Xue, T.; Khan, M.; Xia, X.; Busquets, R.; Gao, H.*; Dong, Y.; Zhou, W.; Deng, R.* Csm6-DNAzyme Tandem Assay for One-Pot and Sensitive Analysis of Lead Pollution and Bioaccumulation in Mice. Analytical Chemistry, 2022, 94, 48, 16953-16959.
70. Gao, H.; Feng, M.; Li, F.; Zhang, K.; Zhang, T.; Zhang, Z.; Yang, C.; Deng, R.*; Zhang, J.*; Jiang, P.* G-Quadruplex DNAzyme-Substrated CRISPR/Cas12 Assay for Label-Free Detection of Single-Celled Parasitic Infection. ACS Sensors, 2022, 7, 2968–2977.
69.Lu, Y.; Li, F.; Bai, J.; Ledesma-Amaro, R.; Liu, D.; He, Q.; Deng, R.* Rapid screening of antimicrobial probiotics using CRISPR cascade. Biosensors and Bioelectronics, 2022, 216, 114673.
2021
68. Tang, Y.; Gao, L.; Feng, W.; Guo, C.; Yang, Q.; Li, F.*; Le, X. C. The CRISPR–Cas toolbox for analytical and diagnostic assay development. Chemical Society Reviews, 2021, 50, 11844-11869. (Inside Cover)
67. Wang, G.A.; Xu, J.; Traynor, S. M.; Chen, H.; Eljabu, F.; Wu, X.; Yan, H.; Li, F.* DNA balance for native characterization of chemically modified DNA. Journal of the American Chemical Society, 2021, 143, 13655–13663.
66. Yang, P.; Zhou, R.; Kong, C.; Fan, L.; Dong, C.; Chen, J.; Hou, X.*; Li, F.* Stimuli-Responsive Three-Dimensional DNA Nanomachines Engineered by Controlling Dynamic Interactions at Biomolecule-Nanoparticle Interfaces. ACS nano, 2021, 15, 16870-16877.
65. Li, Y.; Mansour, H.; Watson, C.; Tang, Y.*; MacNeild, A.; Li, F.* Amplified detection of nucleic acids and proteins using an isothermal proximity CRISPR Cas12a assay. Chemical Science, 2021, 12, 2133-2137.
64. Gao, L.; Liu, L.; Tian, Y.; Yang, Q.; Wu, P.; Fan, C.; Zhao, Q.*; Li, F.* Probing the Formation Kinetics and Thermodynamics with Rationally Designed Analytical Tools Enables One-Pot Synthesis and Purification of a Tetrahedral DNA Nanostructure. Analytical Chemistry, 2021, 93, 7045−7053.（Front Cover)
63. Huang, D.; Han, H.; Guo, C.; Lin, X.; Chen, D.; Yang, S.; Yang, Q. *; Li, F.* Information processing using an integrated DNA reaction network. Nanoscale, 2021, 13, 5706-5713. (Back Cover）
62. Li, X.; Zheng, T.; Xie, Y.; Li, F.*; Jiang, X.; Hou, X.; Wu, P.* Recombinase Polymerase Amplification Coupled with a Photosensitization Colorimetric Assay for Fast Salmonella spp. Testing Analytical Chemistry, 2021. 93, 6559–6566.
61. Le, A. T. H.; Krylova, S. M.; Beloborodov, S. S.; Wang, T. Y.; Hili, R.; Johnson, P. E.; Li, F.; Veedu, R. N.; Belyanskaya, S.; Krylov, S. N.* How to Develop and Prove High-Efficiency Selection of Ligands from Oligonucleotide Libraries: A Universal Framework for Aptamers and DNA-Encoded Small-Molecule Ligands. Analytical Chemistry, 2021, 93, 5343–5354.
60. Fan, L.*; Wang, X.; Zan, Q.; Fan, L.; Li, F.; Yang, Y.; Zhang, C.; Shuang, S.; Dong, C.* Lipid Droplet-Specific Fluorescent Probe for In Vivo Visualization of Polarity in Fatty Liver, Inflammation, and Cancer Models. Analytical Chemistry, 2021, 93, 8019–8026.
59. Wang, X.; Fan, L. *, Wang, S.; Zhang, Y.*; Li, F.; Zan, Q.; Lu, W.; Shuang, S.; Dong C.* Real-Time Monitoring Mitochondrial Viscosity during Mitophagy Using a Mitochondria-Immobilized Near-Infrared Aggregation-Induced Emission Probe. Analytical Chemistry, 2021, 93, 3241–3249.
58. Fan, L.; Liang, G.; Zhang, G.; Fan, L.; Yan, W.; Guo, Y.; Shuang, S.; Bi, Y.; Li, F.; Dong, C.* Visible-light-driven photoelectrochemical sensing platform based on BiOI nanoflowers/TiO2 nanotubes for detection of atrazine in environmental samples. Journal of Hazardous Materials, 2021, 409, 124894
2020
57. Wang, G.A.; Xie, X.; Mansour, H.; Chen, F.; Matamoros, G.; Sanchez, A. L.; Fan, C.; Li, F.* Expanding detection windows for discriminating single nucleotide variants using rationally designed DNA equalizer probes. Nature Communications, 2020, 11, 5473.
56. Traynor, S. M.; Wang, G. A.; Pandey, R.; Li, F.*; Soleymani, L.* Dynamic Bio‐Barcode Assay Enables Electrochemical Detection of a Cancer Biomarker in Undiluted Human Plasma: A Sample‐In‐Answer‐Out Approach. Angewandte Chemie International Edition, 2020, 59, 22617-22622.
55. Lin, X.;Yang, S.;Huang, D.;Guo, C.;Chen, D.;Yang, Q.*; Li, F.* A supramolecular aggregation-based constitutional dynamic
network for information processing. Chemical Science, 2020, 11, 9617-9622.
54. Wang, Y.; Hu, H.; Dong, T.; Mansuor, H.; Zhang, X.; Li, F.*; Wu, P.* Double Stranded DNA Matrix for Photosensitization Switching. CCS Chemistry, 2020, 3, 2394-2404.
53. Dong, T.; Mansour, H.; Hu, H.; Wang, G. A.; Watson, C. J. F.; Yousef, M.; Matamoros, G.; Sanchez, A. L.; MacNeil, A. J.; Wu, P.;* Li, F.* Colorimetric polymerase chain reaction enabled by a fast light-activated substrate chromogenic (FLASH) detection platform. Analytical Chemistry, 2020, 92, 6456-6461.
52. Yang, P.; Li, Y.; Mason, S. D.; Chen, F.; Chen, J.;* Zhou, R.; Liu, J.; Hou, X.; Li, F.* A concentric DNA amplifier that streamlines in-solution biorecognition and on-particle biocatalysis. Analytical Chemistry, 2020, 92，3220-3227.
51. Zhou, R.; Li, Y.; Dong, T.; Tang, Y.;* Li, F.* A sequence-specific plasmonic loop-mediated isothermal amplification assay with orthogonal color readouts enabled by CRISPR Cas12a. Chemical Communications, 2020, 56，3536-3538.
50. Gao, L.; Yang, Q.;* Wu, P.; Li, F.* Recent advances in nanomaterial-enhanced enzyme-linked immunosorbent assays. Analyst, 2020,145, 4069-4078.
49. Tang, W.; Zhong, W.; Tan, Y.; Wang, G. A.; Li, F.*; Liu, Y.* DNA strand displacement reaction: a powerful tool for discriminating single nucleotide variants. Topics in Current Chemistry, 2020, 378, 10-39.
48. Chen, F.;* Mao, M.; Wang, J.; Liu, J.; Li, F.* A dual-step immobilization/imprinting approach to prepare magnetic molecular imprinted polymers for selective removal of human serum albumin. Talanta, 2020, 209, 120509-120516.
46.Tang, Y.; Craven, C.; Wawryk, N.; Qiu, J.; Li, F.; Li, X.-F.* Advances in mass spectrometry-based omics analysis of trace organics in water. Trends in Analytical Chemistry, 2020, 128, 115918-115926.
45. Hosseini, A.; Pandey, R.; Osman, E.; Victorious, A. , Li, F.; Didar, T.; Soleymani, L. * Roadmap to the Bioanalytical Testing of COVID-19: From Sample Collection to Disease Surveillance. ACS Sensors, 2020, 5, 3328–3345.
44. Traynor, S. M.; Pandey, R.; Maclachlan, R.; Hosseini, A.; Didar, T. F.; Li, F.; Soleymani, L. Recent advances in electrochemical detection of prostate specific antigen (PSA) in clinically-relevant samples. Journal of the Electrochemical Society, 2020, 167, 037551-037562.
43. Wang, X.*; Li, F.; Guo, Y.* Recent Trends in Nanomaterial-Based Biosensors for Point-of-Care Testing. Frontiers in Chemistry, 2020, 8, 586702-586707.
2019
42. Mason, S. D.; Wang, G. A.; Yang, P.; Li, Y.; Li, F.* Probing and controlling dynamic interactions at biomolecule-nanoparticle interfaces using stochastic DNA walkers. ACS Nano, 2019, 13, 8106-8113.
41. Li, Y.; Mansour, H.; Wang, T.; Poojari, S.; Li, F.* Naked-eye detection of grapevine red-blotch viral infection using a plasmonic CRISPR Cas12a Assay. Analytical Chemistry, 2019, 91, 11510-11513.
39. Dong, T.; Wang, G. A.; Li, M.; Li, F.* Systematic investigation of quantitative paper-based DNA reader (qPDR) for distance-based quantification of nucleic acids and mercury ions. Analytical Methods, 2019, 11, 5376-5380.
38. Fan, L.;* Wang, X.; Ge, J.; Li, F.;* Zhang, C.; Lin, B.; Shuang, S.; Dong, C.* A golgi-targeted off-on fluorescent probe for real-time monitoring of pH changes in vivo. Chemical Communications, 2019, 55, 6685-6688.
37. Fan, L.;* Wang, X.; Ge, J.; Li, F.;* Wang, X.; Wang, J.; Shuang, S.; Dong, C.* A lysosome-targeting and polarity-specific fluorescent probe for cancer diagnosis. Chemical Communications, 2019, 55, 4703-4706.
36. Li, X.; Gao, L.; Li, F.; Hou, X.; Wu, P.* Universal and label-free photosensitization colorimetric assays enabled by target-induced termini transformation of dsDNA resistant to Exo III digestion. Chemical Communications, 2019, 55, 7211-7214.
35. Wang, X.; Fang L.;* Ge, J.; Li, F.; Zhang, C.; Wang, J.; Shuang, S.; Dong, C. A lysosome-targetable fluorescent probe for real-time imaging cysteine under oxidative stress in living cells. Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy. 2019, 221, 117175.
34. Ding, Y.; Li, X.; Zhang, X.; Li, F.;* Hou, X.; Wu, P.* Systematic probing of the sequence selectivity of exonuclease III with a photosensitization colorimetric assay. ACS Omega, 2019, 4, 13382-13387.
2018
33. Li, Y.; Wang, G, A.; Mason, S. D.; Yang, X.; Yu, Z.; Tang, Y.; Li, F.* Simulation-guided engineering of an enzyme-powered three dimensional DNA nanomachine for discriminating single nucleotide variants. Chemical Science, 2018, 9, 6434-6439.
32. Wang, G. A.; Dong, T.; Mansour H.; Matamoros, G.; Sanchez, A. L.; Li, F.* Paper-Based DNA Reader for Visualized Quantification of Soil-Transmitted Helminth Infections. ACS Sensors, 2018, 3, 205-210
31. Li, F.;* Lin, Y.; Lau, A.; Tang, Y.; Chen, J.; Le, X. C.* Binding-induced molecular amplifier as a universal detection platform for biomolecules and biomolecular interaction. Analytical Chemistry, 2018, 90, 8651-8657.
30. Mason, S.; Tang, Y.; Li, Y.; Xie, X.; Li, F.* Emerging bioanalytial applications of DNA walkers. Trends in Analytical Chemistry, 2018, 107, 212-221.
2017
29. Soleymani, L.;* Li, F.* Mechanistic Challenges and Advantages of Biosensor Miniaturization into the Nanoscale. ACS Sensors, 2017, 2, 458-467
28. Li, F.;* Li, J.; Tang, Y.; Wang, C.; Li, X.-F.; Le, X. C.* Targeted enlargement of aptamer functionalized gold nanoparticles for quantitative protein analysis. Proteomes, 2017, 5, 1.
2016
27. Yang, X.; Tang, Y.; Traynor, S. M.; Li, F.* Regulation of DNA strand displacement using allosteric DNA toehold. Journal of the American Chemical Society, 2016, 138, 14076-14082.
26. Yang, X.; Tang, Y.; Mason, S. D.; Chen, J.; Li, F.* Enzyme-powered three dimensional DNA nanomachine for DNA walking, payload release, and biosensing. ACS Nano, 2016, 10, 2324-2330.
25. Li, F.*; Tang, Y.; Traynor, S. M.; Li, X.-F.; Le, X. C.* Kinetics of proximity-induced intramolecular DNA strand displacement. Analytical Chemistry, 2016, 88, 8152-8157.
24. Tang, Y.; Xu, Y.; Li, F.; Jamiff, L.; Steve, E. Hrudey; Li, X.-F. Non-targeted identification of peptides and disinfection byproducts in water. Journal of Environmental Sciences, 2016, 42, 259-266.
23. Chen, J.; Deng B.; Wu, P.; Li, F.; Li, X.-F.; Le, X. C.; Zhang, H.; Hou, X. Amplified binding-induced homogeneous assay through catalytic cycling of analyte for ultrasensitive protein detection. Chemical Communications, 2016, 52, 1816-1819.
22. Yang, X.; Tang, Y.; Alt, R. R.; Xie, X.; Li, F.* Emerging techniques for ultrasensitive protein analysis. Analyst, 2016, 141, 3473-3481.
2015
21. Tang, Y.; Wang, Z.; Yang, X.; Chen, J.; Liu, L.; Zhao, W.; Le, X. C.; Li, F.* Constructing real-time, wash-free, and reiterative sensors for cell surface proteins using binding-induced dynamic DNA assembly. Chemical Science, 2015, 6, 5729-5733.
20. Tang, Y.; Lin, Y; Yang, X.; Wang, Z.; Le, X. C.; Li, F.* Universal strategy to engineer catalytic DNA hairpin assemblies for protein analysis. Analytical Chemistry, 2015, 87, 8063-8066.
19. Li, F.;# Zhang, H.;#Wang, Z.; Newbigging, M. A.; Reid, S. M..; Li, X.-F.; Le, X. C.* Aptamers facilitate amplified detection of biomolecules. Analytical Chemistry, 2015, 87, 274-292. (# These authorscontributed equally to this paper)
2014 and before
18. Paliwoda, E. R.;# Li, F.;# Reid, S. M.; Lin, Y.; Le, X. C.* Sequential strand displacement beacon for detection of DNA coverage on functionalized gold nanoparticles. Analytical Chemistry, 2014, 86, 6138-6143. (# These authors contributed equally to this paper)
17. Ali, M.M.; Li, F.; Zhang Z.; Zhang, K.; Kang, D.-K.; Ankrum, J.; Le, X. C.; Zhao, W.* Rolling circle amplification: a versatile tool for chemical biology, materials science and medicine. Chemical Society Reviews, 2014, 43, 3324-3341.
16. Deng, B.; Lin, Y.; Wang, C.; Li, F.; Wang, Z.; Zhang, H.; Li, X.-F.; Le, X. C. Aptamer binding assays for proteins: the thrombin example-a review. Analytica Chimica Acta, 2014, 837, 1-15.
15. Zhang, H.#; Li, F.#; Dever, B.; Li, X-F.; Le, X. C.* DNA-mediated homogeneous binding assays for nucleic acids and proteins. Chemical Reviews, 2013, 113, 2812-2841. (# These authors contributed equally to this paper)
14. Li, F.; Zhang, H.; Wang, Z.; Li, X.; Li, X.-F.; Le, X. C.* Dynamic DNA assemblies mediated by binding-induced DNA strand displacement. Journal of the American Chemical Society, 2013, 135, 2443-2446.
13. Zhang, H.; Li, F.; Dever, B.; Wang, C.; Li, X.-F.; Le, X.C.* Assembling DNA through affinity binding to achieve ultrasensitive protein detection. Angewante Chemie International Edition, 2013, 52, 10698-10705.
12. Li, F.; Lin, Y.; Le, X. C.* Binding-induced formation of DNA three-way junctions and its application in real-time protein detection and DNA strand displacement. Analytical Chemistry, 2013, 85, 10835-10841.
11. Li, F.; Zhang, H.; Dever, B.; Li, X.-F.; Le, X. C.* Thermal stability of DNA functionalized gold nanoparticles. Bioconjugate Chemistry, 2013, 24, 1790-1797.
10. Zhang, H.; Li, F.; Li, X.-F.; Le, X. C. Yoctomole detection of proteins using solid phase binding-induced DNA assembly. Methods, 2013, 64, 322-330.
9. Li, F.; Zhang, H..; Lai, C.; Li, X.-F.; Le, X. C.* A molecular translator that acts by binding-induced DNA strand displacement for a homogeneous protein assay. Angewandte Chemie International Edition, 2012, 51, 9317-9320.
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